Liver Cancer Stem Cells Pdf Download

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Activation and proliferation of hepatic progenitor cells have been reported in precancerous conditions, such as chronic inflammation (hepatitis B/hepatitis C, alcoholic hepatitis and steatohepatitis).17and18 Therefore, HPC could be a source of cancer stem cells in HCC.Figure1.Schema of Duct of Haering and niches of HPC.Figure optionsDownload full-size imageDownload as PowerPoint slide3. Download PDF Opens in a new window. According to the latter, at the germinal center of tumor evolution is a cancer stem cell (CSC) which, similar to normal adult stem cells, possesses the capacity of self-renewal and a differentiation potential.Over the past few years, compelling evidence has emerged in support of the hierarchic cancer model for many solid tumors including hepatocellular cancers. In our series, there were 42 patients (31 males, 11 females, aged 23–80 years old) with HCC, who accepted liver resection, yielding specimens sufficient for pathological studies. Please refer to this blog post for more information. Similar to the phenotypic diversity of normal adult tissues that is generated by tissue specific stem cells, the CSC model posits that at the apex of tumor formation is a stem-like cell (commonly referred to as CSC or tumor-initiating cell) that is responsible for the heterogeneity observed within the clonally derived tumors including liver cancer [9], [1], [10]and[2]. The unique features of CSCs (arrows) provide attractive targets (red arrows) for developing novel therapeutic tools directed specifically at the CSC. Please enable JavaScript to use all the features on this page. HPC grading was higher in HCC patients with hepatitis B or hepatitis C and lower in those with non-B or non-C hepatitis. Review Series Hypoxia and Inflammation (Upcoming) Extracellular Vesicles (Apr 2016) HIV (Feb 2016) Cancer Immunotherapy (Sep 2015) Autoimmunity (Jun 2015) Enteric Nervous System (Mar 2015) Autophagy (Jan 2015) View all review series. ScienceDirect is a registered trademark of Elsevier B.V.RELX Group Recommended articles No articles found. The modern tools of stem cell biology have provided strong evidence to show that CSC arise from both normal stem cells and from non self-renewing progenitor cells.19 Importantly, the term “cancer stem cell” is an operative definition that does not necessarily have a developmental relationship to normal stem cells, but a subset of cells within a tumor can self-renew and elaborate tumor heterogeneity.20 Ultimately, the definition depends on the assays of self-renewal and tumorigenicity. Defining features of liver progenitor cellsFour possible hepatic stem cells are identified in the canal of Haering (proximal biliary tree): intralobular bile ducts, periductal “null” mononuclear cells, and peribiliary hepatocytes14 as shown in Fig.1. Without determining the characteristics of CSC, it is impossible to propose new treatment strategies.Keywordscancer stem cell; hepatic progenitor cell; hepatocellular carcinoma; liver stem cell1. 1.CSC properties and mechanisms of regulation. Immunohistochemical studies were made with human monoclonal antibodies against OV-6, CD133, CK-19, CD44, AFP for investigating the HPC. ScienceDirect is a registered trademark of Elsevier B.V.RELX Group Recommended articles No articles found. The 1-, 3-, and 5-year survival rates of Grade 0 and Grade 1–3 were 92%, 76%, and 69%, and 63%, 50%, and 50%, respectively (p=0.073). Clinical Medicine.. Help Direct export Export file RIS(for EndNote, Reference Manager, ProCite) BibTeX Text RefWorks Direct Export Content Citation Only Citation and Abstract Advanced search JavaScript is disabled on your browser. Screen reader users, click the load entire article button to bypass dynamically loaded article content. Marquardt, V.M. (For a more detailed discussion of the potential origin of CSC, we refer to recent reviews [13], [14]and[15]). RNAi, RNA interference machinery; LOH, loss of heterozygosity; CNV, copy number variations; SNP, single nucleotide polymorphism.Figure optionsDownload full-size imageDownload high-quality image (388 K)Download as PowerPoint slideThe CSC model predicts several possible scenarios of how cancer stem cells and tumor heterogeneity may originate [9]and[12], including (i) differentiation arrest of adult tissue stem cell and/or progenitor cell, (ii) dedifferentiation of mature cell, and (iii) transdifferentiation of a stem cell from a different tissue, e.g. Metrics . A description of the basic properties and respective experimental assessment criteria are provided in Table 1. bd40bc7c7a

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